用于脑癌和乳腺癌治疗的微型冷大气等离子体源
Micro-sized cold atmospheric plasma source for brain and breast cancer treatment
摘要：
微尺寸冷大气等离子体（uCAP）的发展拓展了CAP在癌症治疗中的应用。在本文中，应用具有不同喷嘴长度的uCAP装置来研究对脑（胶质母细胞瘤U87）和乳腺（MDA-MB-231）癌细胞的影响。采用各种诊断技术来评估具有不同长度的uCAP器件的参数，例如电势分布、电子密度和光学发射光谱。研究了短寿命和长寿命物种（如羟自由基（.OH）、超氧阴离子（O2-）、过氧化氢（H2 O2）、亚硝酸根（NO2-）等）的产生。这些数据表明，由于活性物质和自由基的协同作用，用20 mm长的管进行uCAP处理比用60 mm长的管进行uCAP处理具有更强的效果。由uCAP产生的反应性物质以剂量依赖性方式增强肿瘤细胞死亡，并且对于肿瘤细胞类型没有特异性。
英文摘要：
Micro-sized cold atmospheric plasma (uCAP) has been developed to expand the applications of CAP in cancer therapy. In this paper, uCAP devices with different nozzle lengths were applied to investigate effects on both brain (glioblastoma U87) and breast (MDA-MB-231) cancer cells. Various diagnostic techniques were employed to evaluate the parameters of uCAP devices with different lengths such as potential distribution, electron density, and optical emission spectroscopy. The generation of short- and long-lived species (such as hydroxyl radical (.OH), superoxide (O2-), hydrogen peroxide (H2O2), nitrite (NO2-), et al) were studied. These data revealed that uCAP treatment with a 20 mm length tube has a stronger effect than that of the 60 mm tube due to the synergetic effects of reactive species and free radicals. Reactive species generated by uCAP enhanced tumor cell death in a dose-dependent fashion and was not specific with regards to tumor cell type.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
