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arXiv 1804.02592stat.ME
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非高斯重复测量数据的线性混合效应模型

Linear Mixed-Effects Models for Non-Gaussian Repeated Measurement Data

Özgür Asar, David Bolin, Peter J. Diggle, Jonas Wallin

摘要:

我们考虑分析通过时间收集的连续重复测量结果,也称为纵向数据。分析这类数据的标准框架是线性高斯混合效应模型,在该模型中,结果变量可以分解为固定效应、时不变和时变随机效应以及测量噪声。我们开发的方法,第一次,允许这些随机成分的任何组合是非高斯的,使用多元正态方差均值混合。我们估计参数的最大似然,实现了一种新的,计算效率高的随机梯度算法。我们通过反转观测到的费舍尔信息矩阵来获得标准误估计,并在过滤(以过去和当前数据为条件)和平滑(以所有数据为条件)上下文中获得随机效应的预测分布。为了实现这些过程,我们引入了一个R包ngme。我们重新分析了两个数据集,从囊性纤维化和肾病研究,这是以前使用高斯线性混合效应模型分析。

英文摘要:

We consider the analysis of continuous repeated measurement outcomes that are collected through time, also known as longitudinal data. A standard framework for analysing data of this kind is a linear Gaussian mixed-effects model within which the outcome variable can be decomposed into fixed-effects, time-invariant and time-varying random-effects, and measurement noise. We develop methodology that, for the first time, allows any combination of these stochastic components to be non-Gaussian, using multivariate Normal variance-mean mixtures. We estimate parameters by max- imum likelihood, implemented with a novel, computationally efficient stochastic gradient algorithm. We obtain standard error estimates by inverting the observed Fisher-information matrix, and obtain the predictive distributions for the random-effects in both filtering (conditioning on past and current data) and smoothing (conditioning on all data) contexts. To implement these procedures, we intro- duce an R package, ngme. We re-analyse two data-sets, from cystic fibrosis and nephrology research, that were previously analysed using Gaussian linear mixed effects models.

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