SIG-DB：利用同态加密来秘密询问私人持有的基因组DataBases
SIG-DB: leveraging homomorphic encryption to Securely Interrogate privately held Genomic DataBases
摘要：
基因组数据变得越来越有价值，因为我们开发了大规模利用信息的方法，并更好地了解遗传信息与生物功能的关系。合成生物学的进步和测序成本的降低正在增加私人持有的基因组数据的数量。随着私人基因组数据的数量和价值的增长，获取和保护这些数据的动机也在增长，这就需要安全地存储和处理这些数据。我们提出了一种基因组数据库的安全查询算法。SIG-DB算法使得能够用加密的查询序列搜索基因组序列的数据库，而不向数据库所有者透露查询序列或向查询者透露任何数据库序列。SIG-DB是第一个利用局部敏感哈希和同态加密来允许基因组数据的广义序列间比较的应用程序。
英文摘要：
Genomic data are becoming increasingly valuable as we develop methods to utilize the information at scale and gain a greater understanding of how genetic information relates to biological function. Advances in synthetic biology and the decreased cost of sequencing are increasing the amount of privately held genomic data. As the quantity and value of private genomic data grows, so does the incentive to acquire and protect such data, which creates a need to store and process these data securely. We present an algorithm for the Secure Interrogation of Genomic DataBases (SIG-DB). The SIG-DB algorithm enables databases of genomic sequences to be searched with an encrypted query sequence without revealing the query sequence to the Database Owner or any of the database sequences to the Querier. SIG-DB is the first application of its kind to take advantage of locality-sensitive hashing and homomorphic encryption to allow generalized sequence-to-sequence comparisons of genomic data.
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