GOTaxon：在基因本体中表示生物功能的进化
GOTaxon: Representing the evolution of biological functions in the Gene Ontology
摘要：
基因本体论的目的是在分子、细胞和生物体水平上定义基因产物已知的功能范围。虽然本体论被设计成以“独立于物种的方式”覆盖生物学的所有方面，但事实仍然是，许多（如果不是大多数）生物学功能被限制在其分类范围内。这仅仅是因为功能在进化，也就是说，像其他生物特征一样，它们在进化过程中获得和失去。在这里，我们介绍了一个通用的方法，表示进化的增益和损失的生物功能的基因本体。然后，我们应用各种技术，包括人工策展，逻辑推理的本体结构，和以前发表的“分类约束”，以分配进化的增益和损失事件的大部分条款在GO。这些增益和损失事件现在几乎是具有分类单元约束的术语数量的三倍，并且目前覆盖了总共76%的GO术语，包括40%的分子功能术语、78%的细胞组分术语和89%的生物过程术语。数据库URL：GOTaxon可在https://github.com/haimingt/GOTaxonConstraint上免费获得
英文摘要：
The Gene Ontology aims to define the universe of functions known for gene products, at the molecular, cellular and organism levels. While the ontology is designed to cover all aspects of biology in a "species independent manner", the fact remains that many if not most biological functions are restricted in their taxonomic range. This is simply because functions evolve, i.e. like other biological characteristics they are gained and lost over evolutionary time. Here we introduce a general method of representing the evolutionary gain and loss of biological functions within the Gene Ontology. We then apply a variety of techniques, including manual curation, logical reasoning over the ontology structure, and previously published "taxon constraints" to assign evolutionary gain and loss events to the majority of terms in the GO. These gain and loss events now almost triple the number of terms with taxon constraints, and currently cover a total of 76% of GO terms, including 40% of molecular function terms, 78% of cellular component terms, and 89% of biological process terms. Database URL: GOTaxon is freely available at https://github.com/haimingt/GOTaxonConstraint
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
