arXiv 1802.025402018-02q-bio.MNq-bio.GN

组胺合成的分子调控

Molecular Regulation of Histamine Synthesis

Hua Huang, Yapeng Li, Jinyi Liang, Fred D. Finkelman

备注：: 1.added references for introduction section; 2.added references and typos added for histamine-producing cells in mammals and stimuli that trigger histamine release; 3.typos added for section of histidine decarboxylase and histamine synthesis in mammals; 4.added references and typos added for section of hdc gene expression and histamine synthesis in basophils and mast cells. 5. added 2 figures

摘要：

组胺是IgE/细胞介导的过敏反应的关键介质、神经递质和胃酸分泌的调节剂。组胺是由氨基酸组氨酸通过组氨酸脱羧酶（HDC）催化的反应合成的单胺，所述组氨酸脱羧酶（HDC）从组氨酸去除羧基。尽管组胺的重要性，哺乳动物中HDC基因表达的转录调控仍然知之甚少。本文就哺乳动物组胺合成的分子调控研究进展作一综述。

英文摘要：

Histamine is a critical mediator of IgE/ cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Despite the importance of histamine, transcriptional regulation of HDC gene expression in mammals is still poorly understood. In this Review, we focus on discussing advances in the understanding of molecular regulation of mammalian histamine synthesis.

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