活体小鼠脑组织结构-刚度关系的深度控制压痕成像研究
Structure-stiffness relation of live mouse brain tissue determined by depth-controlled indentation mapping
摘要：
脑组织的力学性质在神经发育和神经系统疾病中起着关键作用。然而，目前，对于组织的不同结构部分如何促成其刚度变化还没有达成共识。在这里，我们已经收集了深度控制压痕粘弹性地图的海马孤立的水平活小鼠脑切片。我们的研究结果证实了材料的高粘弹性性质，并清楚地表明，机械性能与不同形态层的样品研究。有趣的是，相对细胞核面积似乎与观察到的硬度呈负相关。
英文摘要：
The mechanical properties of brain tissue play a pivotal role in neurodevelopment and neurological disorders. Yet, at present, there is no consensus on how the different structural parts of the tissue contribute to its stiffness variations. Here, we have gathered depth-controlled indentation viscoelasticity maps of the hippocampus of isolated horizontal live mouse brain sections. Our results confirm the highly viscoelestic nature of the material and clearly show that the mechanical properties correlate with the different morphological layers of the samples investigated. Interestingly, the relative cell nuclei area seems to negatively correlate with the stiffness observed.
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