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arXiv 1801.02597stat.MEstat.CO
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聚类数据模型中的蒙特卡罗修正轮廓似然法

Monte Carlo modified profile likelihood in models for clustered data

Claudia Di Caterina, Giuliana Cortese, Nicola Sartori

摘要:

处理聚类数据的分析师的主要焦点通常不是聚类变量,因此特定于组的参数被视为讨厌的东西。如果一个固定效应配方是首选和集群的总数是相对于单组大小大,经典的频率依赖于配置文件的可能性技术往往是误导。由于存在非标准建模和/或抽样假设,使用替代工具,如修改轮廓似然或综合似然,对感兴趣的参数进行准确推断可能会变得复杂。我们在这里展示了如何采用蒙特卡罗模拟,以近似修改后的配置文件的可能性,在这些非常规的框架。所提出的解决方案是广泛适用的,并保持通常的属性修改后的配置文件的可能性。该方法在两种情况下,特别是相关的应用程序,即缺失数据模型和生存模型与未指定的删失分布进行检查。通过仿真研究和两个临床试验应用验证了所提出的解决方案的有效性。

英文摘要:

The main focus of the analysts who deal with clustered data is usually not on the clustering variables, and hence the group-specific parameters are treated as nuisance. If a fixed effects formulation is preferred and the total number of clusters is large relative to the single-group sizes, classical frequentist techniques relying on the profile likelihood are often misleading. The use of alternative tools, such as modifications to the profile likelihood or integrated likelihoods, for making accurate inference on a parameter of interest can be complicated by the presence of nonstandard modelling and/or sampling assumptions. We show here how to employ Monte Carlo simulation in order to approximate the modified profile likelihood in some of these unconventional frameworks. The proposed solution is widely applicable and is shown to retain the usual properties of the modified profile likelihood. The approach is examined in two instances particularly relevant in applications, i.e. missing-data models and survival models with unspecified censoring distribution. The effectiveness of the proposed solution is validated via simulation studies and two clinical trial applications.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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