DCJVis：使用DCJ操作的基因组重排的可视化
DCJVis: visualization of genome rearrangements using DCJ operations
摘要：
由Yancopoulos \emph{et al.}引入的{ \em double-cut-and-join}（DCJ）操作允许通过在两个基因组之间的线性时间中对所有可能的经典重排操作（例如倒位、融合、分裂、易位和转置）进行建模来计算最小编辑距离。然而，有缺乏可视化工具，可以有效地呈现DCJ操作，这将有助于生物学家使用DCJ操作。在本文中，介绍了一种新的可视化程序，DCJVis，创建一个图表，每个DCJ操作必要的两个不同的生物体的基因组之间的转换，通过描述一个可能的序列的基因组图的基础上选择的基因邻接的源基因组的DCJ操作。我们的程序是第一个使用圆形布局的DCJ操作的可视化工具。具体来说，基因组的\textit{Saccharomyces cerevisiae}和\textit{Candida albicans}用于演示该程序的功能，并提供了一个例子的类型的问题，该程序可以解决生物学家。
英文摘要：
The {\em double-cut-and-join} (DCJ) operation, introduced by Yancopoulos \emph{et al.}, allows minimum edit distance to be computed by modeling all possible classical rearrangement operations, such as inversions, fusions, fissions, translocations, and transpositions, in linear-time between two genomes. However, there is lack of visualization tool that can effectively present DCJ operations that will help biologists to use DCJ operation. In this paper, a new visualization program is introduced, DCJVis, to create a diagram of each DCJ operation necessary to transform between the genomes of two distinct organisms by describing a possible sequence of genome graphs based on the selected gene adjacency on the source genome for the DCJ operation. Our program is the first visualization tool for DCJ operations using circular layout. Specifically, the genomes of \textit{Saccharomyces cerevisiae} and \textit{Candida albicans} are used to demonstrate the functionality of this program and provide an example of the type of problem this program can solve for biologists.
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