细菌合作导致异源耐药性
Bacterial cooperation leads to heteroresistance
摘要：
通过挑战E.用亚致死的诺氟沙星对大肠杆菌进行10天的研究，亨利·李和詹姆斯·柯林斯认为细菌的利他主义导致了整个种群的耐药性。通过对实验数据的详细分析，我们认为在诺氟沙星压力下，细菌之间的合作导致了群体性耐药，同时提出细菌屏障可能是低耐药菌的反馈机制。细菌屏障是指耐药率较低的细菌牺牲自身大量消耗诺氟沙星，从而减轻耐药率较高的细菌对诺氟沙星的负荷。因此，由于从同一细菌群体中提取的高抗性细菌和低抗性细菌，细菌合作导致异源抗性。
英文摘要：
By challenging E. coli with sublethal norfloxacin for 10 days, Henry Lee and James Collins suggests the bacterial altruism leads to the population-wide resistance. By detailedly analyzing experiment data, we suggest that bacterial cooperation leads to population-wide resistance under norfloxacin pressure and simultaneously propose the bacteria shield is the possible feedback mechanism of less resistant bacteria. The bacteria shield is that the less resistant bacteria sacrifice the large number of themselves to consume norfloxacin and then to relieve the norfloxacin burden from highly resistant bacteria. Thus, due to highly resistant bacteria and less resistant bacteria extracted from the same bacteria population, bacterial cooperation leads to heteroresistance.
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