用于药物定量的可扩展石墨烯适体传感器
Scalable Graphene Aptasensors for Drug Quantification
摘要：
非常需要用于治疗药物水平监测的更简单和更快速的方法，以能够在护理点使用。我们已经开发了一种全电子方法，用于检测HIV药物替诺福韦，该方法基于用市售DNA适体功能化的石墨烯场效应晶体管（GFET）阵列的可扩展制造。GFET的狄拉克电压的偏移随着去离子水中替诺福韦的浓度而系统地变化，检测限小于1 ng/mL。针对一组阴性对照品的试验证实了探头响应的特异性。这种方法提供了进一步发展成为具有临床相关性能的快速方便的床旁工具的潜力。
英文摘要：
Simpler and more rapid approaches for therapeutic drug-level monitoring are highly desirable to enable use at the point-of-care. We have developed an all-electronic approach for detection of the HIV drug tenofovir based on scalable fabrication of arrays of graphene field-effect transistors (GFETs) functionalized with a commercially available DNA aptamer. The shift in the Dirac voltage of the GFETs varied systematically with the concentration of tenofovir in deionized water, with a detection limit less than 1 ng/mL. Tests against a set of negative controls confirmed the specificity of the sensor response. This approach offers the potential for further development into a rapid and convenient point-of-care tool with clinically relevant performance.
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