基于网络和基于两两序列比对的树状图重建方法之间差异的大规模评估
Large scale evaluation of differences between network-based and pairwise sequence-alignment-based methods of dendrogram reconstruction
摘要：
树状图是一种表示生物体之间进化关系的方法。如今，这些都是基于基因或蛋白质序列的比较，通过考虑它们的差异和相似性来推断的。选择用于序列比对的遗传物质（所有基因或基因组）产生不同的推断树状图。在这项工作中，我们评估了不同的方法重建的树状图之间的差异，并从一个更大的集合中随机选择不同的生物体。进行统计分析，以估计从不同方法获得的结果之间的波动。这种分析使我们能够验证一个系统的方法，基于生物体的代谢网络的比较，推断树状图。它的优点是，它允许在进化树中非常遥远的生物体进行比较，即使它们没有已知的共同直系同源基因。
英文摘要：
Dendrograms are a way to represent evolutionary relationships between organisms. Nowadays, these are inferred based on the comparison of genes or protein sequences by taking into account their differences and similarities. The genetic material of choice for the sequence alignments (all the genes or sets of genes) results in distinct inferred dendrograms. In this work, we evaluate differences between dendrograms reconstructed with different methodologies and obtained for different sets of organisms chosen at random from a much larger set. A statistical analysis is performed in order to estimate the fluctuation between the results obtained from the different methodologies. This analysis permit us to validate a systematic approach, based on the comparison of the organisms' metabolic networks for inferring dendrograms. It has the advantage that it allows the comparison of organisms very far away in the evolutionary tree even if they have no known ortholog gene in common.
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