IFG中的网络可控性与受控语言可变性和对TMS的敏感性有关
Network Controllability in the IFG Relates to Controlled Language Variability and Susceptibility to TMS
摘要：
在语言产生过程中，人类面临着大量的选词需求。通常，我们必须从相似的、可接受的和竞争性的替代词中选择一个词，以构建一个表达预期含义的句子。近年来，左额下回（LIFG）已被确定为这种能力的关键。尽管最近强调了理解语言的网络方法，但LIFG如何与大脑的复杂网络相互作用以促进受控的语言表现仍然是未知的。在这里，我们采取了一种新的方法来理解单词选择作为大脑中的网络控制过程。使用来自高分辨率扩散谱成像（DSI）的解剖脑网络，我们计算了两个单词选择任务之间的管理LIFG中的经颅磁刺激位点的网络可控性。我们发现，量化的LIFG的理论预测控制难以达到的状态的统计解释的脆弱性TMS的语言任务，不同的响应（认知控制）的要求：开放响应（字生成）与封闭响应（数字命名）的任务。此外，我们发现，量化的LIFG的理论预测控制的通信模块在人类连接体的统计解释TMS引起的变化，在开放式响应语言任务的性能。这些发现建立了网络可控性，认知功能和TMS效应之间的联系。
英文摘要：
In language production, humans are confronted with considerable word selection demands. Often, we must select a word from among similar, acceptable, and competing alternative words in order to construct a sentence that conveys an intended meaning. In recent years, the left inferior frontal gyrus (LIFG) has been identified as critical to this ability. Despite a recent emphasis on network approaches to understanding language, how the LIFG interacts with the brain's complex networks to facilitate controlled language performance remains unknown. Here, we take a novel approach to understand word selection as a network control process in the brain. Using an anatomical brain network derived from high-resolution diffusion spectrum imaging (DSI), we computed network controllability underlying the site of transcranial magnetic stimulation in the LIFG between administrations of two word selection tasks. We find that a statistic that quantifies the LIFG's theoretically predicted control of difficult-to-reach states explains vulnerability to TMS in language tasks that vary in response (cognitive control) demands: open-response (word generation) vs. closed-response (number naming) tasks. Moreover, we find that a statistic that quantifies the LIFG's theoretically predicted control of communication across modules in the human connectome explains TMS-induced changes in open-response language task performance only. These findings establish a link between network controllability, cognitive function, and TMS effects.
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