通过细胞-细胞粘附产生集体推进
Emergence of collective propulsion through cell-cell adhesion
摘要：
驱动细胞集体运动的机制仍然知之甚少。为了解决这个问题，我们建立了一个模型，从理论上探讨极化细胞间粘附在集体细胞迁移中的可能作用。该模型由具有极化细胞-细胞粘附的阿米巴细胞组成，其由细胞运动的正反馈控制。这个模型细胞没有持续的推进力，因此在隔离时表现出简单的随机行走。然而，在高密度下，这些细胞获得集体推进并形成有序的运动。这一结果表明，细胞-细胞粘附具有潜在的功能，诱导持久的集体推进。
英文摘要：
The mechanisms driving the collective movement of cells remain poorly understood. To contribute toward resolving this mystery, a model was formulated to theoretically explore the possible functions of polarized cell-cell adhesion in collective cell migration. The model consists of an amoeba cell with polarized cell-cell adhesion, which is controlled by positive feedback with cell motion. This model cell has no persistent propulsion, and therefore exhibits a simple random walk when in isolation. However, at high density, these cells acquire collective propulsion and form ordered movement. This result suggests that cell-cell adhesion has a potential function, which induces collective propulsion with persistence.
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