石墨烯微电极用于工程蛋白-纳米颗粒组装体的结构-功能分析
Structural-Functional Analysis of Engineered Protein-Nanoparticle Assemblies Using Graphene Microelectrodes
摘要：
在溶液中的蛋白质-纳米颗粒组装体的表征仍然是一个挑战。我们展示了一种基于石墨烯微电极的技术，用于由封闭在开孔和闭孔铁蛋白分子中的纳米颗粒组成的模型系统的结构-功能分析。该方法很容易解决封闭的纳米粒子的电荷转移的可及性的差异，并提供了对孔介导的运输阐明纳米粒子表面上的蛋白质亚基的空间取向的定量分析的前景，比传统的催化方法更快，更高的灵敏度。
英文摘要：
The characterization of protein-nanoparticle assemblies in solution remains a challenge. We demonstrate a technique based on a graphene microelectrode for structural-functional analysis of model systems composed of nanoparticles enclosed in open-pore and closed-pore ferritin molecules. The method readily resolves the difference in accessibility of the enclosed nanoparticle for charge transfer and offers the prospect for quantitative analysis of pore-mediated transport shed light on the spatial orientation of the protein subunits on the nanoparticle surface, faster and with higher sensitivity than conventional catalysis methods.
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