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arXiv 1708.06451math.OCq-bio.PE
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一类时滞HIV模型的最优控制

Optimal control of a delayed HIV model

Filipe Rodrigues, Cristiana J. Silva, Delfim F. M. Torres, Helmut Maurer

摘要:

提出了一个具有细胞内时滞的HIV-1感染模型,证明了该模型的平衡点的局部渐近稳定性。然后,我们引入了一个控制功能,代表逆转录酶抑制剂的效率,并考虑与控制相关的药理学延迟。最后,我们提出并分析了一个具有状态和控制时滞的最优控制问题。通过数值模拟,提出了最小化病毒浓度和处理成本的极值解。

英文摘要:

We propose a model for the human immunodeficiency virus type 1 (HIV-1) infection with intracellular delay and prove the local asymptotical stability of the equilibrium points. Then we introduce a control function representing the efficiency of reverse transcriptase inhibitors and consider the pharmacological delay associated to the control. Finally, we propose and analyze an optimal control problem with state and control delays. Through numerical simulations, extremal solutions are proposed for minimization of the virus concentration and treatment costs.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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