基于网络的饮食搜索模式对B12缺乏在慢性疼痛中作用的证据
Evidence from web-based dietary search patterns to the role of B12 deficiency in chronic pain
摘要：
严重的维生素B12缺乏症是一种已知的疾病原因，但低或中等水平的B12在神经病变和其他神经精神症状的发展中的作用以及吃肉和B12水平的关系尚不清楚。在这里，我们使用来自850万美国人样本的与食物相关的互联网搜索模式作为B12摄入量的代理，并将这些搜索与B12缺乏可能影响的互联网搜索相关联。食物相关的搜索模式与已知的消费和食物相关的搜索高度相关（斯皮尔曼0.69）。B12缺乏的意识与富含B12的食物的消费量增加以及B12补充剂的查询有关。与对照组相比，神经系统疾病相关术语的搜索与B12缺乏食物的搜索相关。流行的药物，那些具有较少的适应症，和那些主要用于治疗疼痛的药物与使用食物中的B12含量预测神经性疼痛查询的能力更强相关。我们的研究结果为使用互联网搜索模式来调查大量人群的健康问题提供了证据，并表明低B12摄入量可能与比目前认识到的更广泛的神经系统疾病相关。
英文摘要：
Profound vitamin B12 deficiency is a known cause of disease, but the role of low or intermediate levels of B12 in the development of neuropathy and other neuropsychiatric symptoms as well as the relationship of eating meat and B12 levels is unclear. Here we use food-related internet search patterns from a sample of 8.5 million US-based people as a proxy to B12 intake and correlate these searches with internet searches related to possible effects of B12 deficiency. Food-related search patterns are highly correlated with known consumption and food-related searches (Spearman 0.69). Awareness of B12 deficiency was associated with a higher consumption of B12-rich foods and with queries for B12 supplements. Searches for terms related to neurological disorders were correlated with searches for B12-poor foods, in contrast with control terms. Popular medicines, those having fewer indications, and those which are predominantly used to treat pain are more strongly correlated with the ability to predict neuropathic pain queries using the B12 contents of food. Our findings provide evidence for the utility of using Internet search patterns to investigate health questions in large populations and suggest that low B12 intake may be associated with a broader spectrum of neurological disorders than currently appreciated.
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