高燃料消耗率并不需要绝缘图案来抑制生物化学回路中的追溯性
High rates of fuel consumption are not required by insulating motifs to suppress retroactivity in biochemical circuits
摘要：
当分子网络$\mathcal{U}$与下游网络$\mathcal{D}$的偶联导致信号从$\mathcal{D}$传播回$\mathcal{U}$时，出现追溯性。这种现象代表了生化电路模块化的故障，并阻碍了复杂功能网络的合理设计。考虑到信号转导架构的简单模型，我们证明了追溯性对上游系统特性的强烈依赖性，并探索了可以减轻追溯效应的消耗燃料的绝缘基序的成本和功效。我们发现，简单的绝缘图案可以抑制追溯性，在低燃料成本的耦合只有微弱的上游系统$\mathcal{U}$。然而，这种设计方法降低了信号网络对泄漏反应扰动的鲁棒性，并可能损害其响应快速变化信号的能力。
英文摘要：
Retroactivity arises when the coupling of a molecular network $\mathcal{U}$ to a downstream network $\mathcal{D}$ results in signal propagation back from $\mathcal{D}$ to $\mathcal{U}$. The phenomenon represents a breakdown in modularity of biochemical circuits and hampers the rational design of complex functional networks. Considering simple models of signal-transduction architectures, we demonstrate the strong dependence of retroactivity on the properties of the upstream system, and explore the cost and efficacy of fuel-consuming insulating motifs that can mitigate retroactive effects. We find that simple insulating motifs can suppress retroactivity at a low fuel cost by coupling only weakly to the upstream system $\mathcal{U}$. However, this design approach reduces the signalling network's robustness to perturbations from leak reactions, and potentially compromises its ability to respond to rapidly-varying signals.
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