用于分析易位生物分子的零深度纳米孔毛细管
A zero-depth nanopore capillary for the analysis of translocating biomolecules
摘要：
通过纳米孔转移生物分子的高保真分析需要将纳米毛细管长度缩短到最小值。然而，现有的纳米孔和毛细管从母膜继承了有限的长度。在这里，我们通过溶解两个叠加和交叉的金属纳米棒形成零深度的纳米胶囊，从而打开在聚合物树脂中模制的两个重叠的纳米流体通道。在电解质中，由交叉流体通道共享的界面在数学上为零厚度，并且限定了通过纳米孔装置的离子流中的最西收缩。这种新颖的架构提供了设计纳米孔流体通道的可能性，特别是具有独立于流体通道的厚度保持最终零厚度几何形状的稳健的3D架构。与2D材料中的纳米孔相比，生物分子易位速度降低了几个数量级，电子和离子噪声降低了，我们的研究结果将界面纳米孔建立为实现纳米流体系统的可扩展平台，能够进行单分子检测。
英文摘要：
High-fidelity analysis of translocating biomolecules through nanopores demands shortening the nanocapillary length to a minimal value. Existing nanopores and capillaries, however, inherit a finite length from the parent membranes. Here, we form nanocapillaries of zero depth by dissolving two superimposed and crossing metallic nanorods, thereby opening two overlapping nanofluidic channels molded in a polymeric resin. In an electrolyte, the interface shared by the crossing fluidic channels is mathematically of zero thickness and defines the narrowest constriction in the stream of ions through the nanopore device. This novel architecture provides the possibility to design nanopore fluidic channels, particularly with a robust 3D architecture maintaining the ultimate zero thickness geometry independently of the thickness of the fluidic channels. With orders of magnitude reduced biomolecule translocation speed, and lowered electronic and ionic noise compared to nanopores in 2D materials, our findings establish interfacial nanopores as a scalable platform for realizing nanofluidic systems, capable of single-molecule detection.
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