PNS髓鞘的内在动力学波动
Intrinsic dynamical fluctuations of PNS myelin
摘要：
髓鞘的多层膜结构的超微结构波动和复杂的动力学是理解和控制其形成过程及其在神经系统疾病如多发性硬化（MS）中的变性和修复的基础。髓磷脂被认为是一种液晶，但由于现有标准技术的限制，信息仅限于其平均结构。为了克服这项工作中的这一限制，我们使用了扫描微X射线衍射（SμXRD），这是一种独特的非侵入性探针，可以在k空间和真实空间中以高空间分辨率可视化髓鞘中的无序。我们用这种方法研究了非洲爪蟾坐骨神经中的髓鞘。我们的研究结果可以为理解髓鞘的形成和降解开辟新的途径。
英文摘要：
The ultrastructure fluctuations and complex dynamics of the multi-layered membrane structure of myelin are fundamental for understanding and control its formation process and its degeneration and repair in neurological diseases such as multiple sclerosis (MS). Myelin is considered a liquid-crystal but information are confined to its average structure due to limitations of the available standard techniques. To overcome this limitation in this work we have used Scanning micro X-ray Diffraction (SμXRD) which is a unique non-invasive probe of both k-space and real space allowing to visualize disorder in myelin with high spatial resolution in real space. We have used this method to examine the myelin sheath in the sciatic nerve of Xenopus laevis. Our results open could open new venues for understanding formation and degradation of myelin.
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