控制神经和神经胶质细胞的形态和生长：表面地形的影响
Controlling the morphology and outgrowth of nerve and neuroglial cells: The effect of surface topography
摘要：
与其他组织类型不同，如上皮组织，其由具有更均匀的结构和功能的细胞组成，神经组织跨越复杂的多层环境，其地形特征显示出大范围的形态和大小尺度。基于二维细胞粘附培养皿或盖玻片的传统细胞培养缺乏地形线索，并且主要模拟细胞的生化微环境。随着微米和纳米制造技术的出现，开发了新型的细胞培养平台，其中可以研究各种地形线索对细胞形态、增殖和分化的影响。不同的方法（关于材料，制造技术，地形特征等）已经实施。本审查文件的目的是审查现有的机构的文献中使用的人工微米和纳米形貌特征，以控制神经元的形态，生长和神经网络拓扑结构。从现象学的基本机制的调查-在不同的地形，包括确定性和随机的细胞反应，进行了总结。
英文摘要：
Unlike other tissue types, like epithelial tissue, which consist of cells with a much more homogeneous structure and function, the nervous tissue spans in a complex multilayer environment whose topographical features display a large spectrum of morphologies and size scales. Traditional cell cultures, which are based on two-dimensional cell-adhesive culture dishes or coverslips, are lacking topographical cues and mainly simulate the biochemical microenvironment of the cells. With the emergence of micro- and nano-fabrication techniques new types of cell culture platforms are developed, where the effect of various topographical cues on cellular morphology, proliferation and differentiation, can be studied. Different approaches (regarding the material, fabrication technique, topographical charactertistics, etc.) have been implemented. The present review paper aims at reviewing the existing body of literature on the use of artificial micro- and nano-topographical features to control neuronal morphology, outgrowth and neural network topology. The cell responses from phenomenology to investigation of the underlying mechanisms- on the different topographies, including both deterministic and random ones, are summarized.
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