C.的长程相关和分形动力学。线虫：随着衰老和压力的变化
Long-range correlations and fractal dynamics in C. elegans: changes with aging and stress
摘要：
运动控制能力下降是与衰老和疾病相关的最常见的特征之一。非线性和分形分析已被证明是有用的，在调查人体生理变化与年龄和疾病。然而，生物学家通常研究的任何模式生物都没有类似的发现。如果一个更简单的模式生物的生理学表现出相同的特征，这一事实将打开一个新的研究窗口，生物体用于调节衰老和应激过程中的生理过程的控制机制。在这里，我们使用最近推出的动物跟踪技术，同时遵循数十个秀丽隐杆线虫数小时，并使用分形生理学的工具，以定量评估老化和温度应激对线虫运动的影响。与人类生理信号类似，尺度分析揭示了许多运动变量的长程相关性，行为变化的分形特性，以及在广泛的时间尺度上的波动动态。这些属性的变化是由于年龄和压力相关的适应机制，调节运动的叠加。
英文摘要：
Reduced motor control is one of the most frequent features associated with aging and disease. Nonlinear and fractal analyses have proved to be useful in investigating human physiological alterations with age and disease. Similar findings have not been established for any of the model organisms typically studied by biologists, though. If the physiology of a simpler model organism displays the same characteristics, this fact would open a new research window on the control mechanisms that organisms use to regulate physiological processes during aging and stress. Here, we use a recently introduced animal tracking technology to simultaneously follow tens of Caenorhabdits elegans for several hours and use tools from fractal physiology to quantitatively evaluate the effects of aging and temperature stress on nematode motility. Similarly to human physiological signals, scaling analysis reveals long-range correlations in numerous motility variables, fractal properties in behavioral shifts, and fluctuation dynamics over a wide range of timescales. These properties change as a result of a superposition of age and stress-related adaptive mechanisms that regulate motility.
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