通过计算象限斜率指数（QSI）量化化生性肿瘤中隐藏的结构模式
Quantifying Hidden Architectural Patterns in Metaplastic Tumors by Calculating the Quadrant-Slope Index (QSI)
摘要：
创建象限斜率指数（QSI）方法是为了检测具有化生元素（如梭形细胞流）的肿瘤图像中的细微组织模式[1]。然而，化生性肿瘤也有细胞核，可能像溪流一样排列，但对病理学家来说并不明显，因为细胞质的形状不清楚。我开发的先前方法，最近邻角轮廓（N-NAP）方法[2]，基于乳腺肿瘤细胞试图将自己并排排列（像砖块一样）的假设，适用于检测细微的有序模式，就像正常乳腺的腔室一样[3]。然而，这种假设对于检测头对尾的细胞排列（例如纺锤体细胞流）并不是最佳的。乳腺化生癌（即基底样乳腺癌、三阴性乳腺癌）被认为来源于正常乳腺基底/肌上皮区室中的干细胞或祖细胞[3中的综述]。基底/肌上皮区室中的上皮细胞以首尾相连的方式排列，形成围绕腔室的网[3，4]。如果化生性肿瘤中的癌细胞试图变得正常，那么检测它们试图正常排列的细微区域的最佳方法应该突出细胞的首尾对齐。
英文摘要：
The Quadrant-Slope Index (QSI) method was created in order to detect subtle patterns of organization in tumor images that have metaplastic elements, such as streams of spindle cells [1]. However, metaplastic tumors also have nuclei that may be aligned like a stream but are not obvious to the pathologist because the shape of the cytoplasm is unclear. The previous method that I developed, the Nearest-Neighbor Angular Profile (N-NAP) method [2], is good for detecting subtle patterns of order based on the assumption that breast tumor cells are attempting to arrange themselves side-by-side (like bricks), as in the luminal compartment of a normal mammary gland [3]. However, this assumption is not optimal for detecting cellular arrangements that are head-to-tail, such as in streams of spindle cells. Metaplastic carcinomas of the breast (i.e. basal-like breast cancers, triple-negative breast cancers) are believed to be derived from the stem or progenitor cells that reside in the basal/myoepithelial compartment of the normal mammary gland [Reviewed in 3]. Epithelial cells in the basal/myoepithelial compartment arrange themselves in an head-to-tail fashion, forming a net that surrounds the luminal compartment [3,4]. If cancer cells in a metaplastic tumor are trying to be normal, the optimal way to detect subtle regions of them attempting to be ordered normally should highlight the head-to-tail alignment of cells.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
