使用固有光学折射率的活细胞中的无标记三维（3D）结构成像
Label-free three-dimensional (3D) structural imaging in live cells using intrinsic optical refractive index
摘要：
在这里，我们报告了一种方法，用于可视化的体积结构信息的活的生物样品，没有外源性造影剂。该过程是通过一种技术，涉及生成，合成和分析的三维（3D）傅立叶分量的光衍射的样品。这导致定量细胞形态的直接恢复，而无需迭代程序以降低计算复杂性。结合的事实，该技术是很容易适应任何成像平台，需要最少的样品制备，我们提出的方法是特别有前途的观察快速，体积和动态的事件以前只能通过染色方法。
英文摘要：
Here we report a method for visualization of volumetric structural information of live biological samples with no exogenous contrast agents. The process is made possible through a technique that involves generation, synthesis and analysis of three-dimensional (3D) Fourier components of light diffracted by the sample. This leads to the direct recovery of quantitative cellular morphology with no iterative procedures for reduced computational complexity. Combing with the fact that the technique is easily adaptive to any imaging platform and requires minimum sample preparation, our proposed method is particularly promising for observing fast, volumetric and dynamic events previously only accessible through staining methods.
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