蛋白质生物电子学：我们知道什么和不知道什么
Protein bioelectronics: a review of what we do and do not know
摘要：
本文综述了蛋白质分子电子学的研究现状。首先，我们讨论了电子转移和运输的基本概念和跨蛋白质和提出这些过程的机制。然后，我们描述了在纳米级和宏观方法的蛋白质固定到固态表面，并强调不同的方法可以改变蛋白质的电子特性。由于固定蛋白质，同时保留生物活性是至关重要的生物电子器件的成功开发，我们讨论这个过程的长度。我们简要讨论计算预测和实验结果的联系。然后，我们总结了固定化蛋白质的生物活性是如何有利于生物电子器件，以及电导测量如何揭示蛋白质的性质。最后，我们考虑如何研究到目前为止可能会影响未来的生物电子设备的发展。
英文摘要：
We review the status of protein-based molecular electronics. First we discuss fundamental concepts of electron transfer and transport in and across proteins and proposed mechanisms for these processes. We then describe the immobilization of proteins to solid-state surfaces in both nanoscale and macroscopic approaches, and highlight how different methodologies can alter protein electronic properties. Because immobilizing proteins while retaining biological activity is crucial to the successful development of bioelectronic devices, we discuss this process at length. We briefly discuss computational predictions and their link to experimental results. We then summarize how the biological activity of immobilized proteins is beneficial for bioelectronics devices, and how conductance measurements can shed light on protein properties. Finally, we consider how the research to date could influence the development of future bioelectronics devices.
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