星形胶质细胞在慢波节律发生中的因果作用：一个计算模型研究
The Causal Role of Astrocytes in Slow-Wave Rhythmogenesis: A Computational Modelling Study
摘要：
找到慢振荡和超慢振荡的起源可以揭示或解释健康和疾病的大脑机制。在这里，我们提出了一个生物病理学约束的计算模型的神经网络，其中包括星形胶质细胞引入缓慢和超慢振荡，通过两种不同的机制。具体而言，我们展示了星形胶质细胞如何通过其缓慢的细胞间钙波速度和振幅来调节快速网络活动，并可能导致在通常已知的此类异常疾病中观察到的振荡失衡，即阿尔茨海默病，帕金森病，癫痫，抑郁症和缺血性中风。这项工作旨在增加我们对星形胶质细胞和神经元如何协同影响大脑功能和功能障碍的了解。
英文摘要：
Finding the origin of slow and infra-slow oscillations could reveal or explain brain mechanisms in health and disease. Here, we present a biophysically constrained computational model of a neural network where the inclusion of astrocytes introduced slow and infra-slow-oscillations, through two distinct mechanisms. Specifically, we show how astrocytes can modulate the fast network activity through their slow inter-cellular calcium wave speed and amplitude and possibly cause the oscillatory imbalances observed in diseases commonly known for such abnormalities, namely Alzheimer's disease, Parkinson's disease, epilepsy, depression and ischemic stroke. This work aims to increase our knowledge on how astrocytes and neurons synergize to affect brain function and dysfunction.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
