In many fields of research null hypothesis significance tests and p values are the accepted way of assessing the degree of certainty with which research results can be extrapolated beyond the sample studied. However, there are very serious concerns about the suitability of p values for this purpose. An alternative approach is to cite confidence intervals for a statistic of interest, but this does not directly tell readers how certain a hypothesis is. Here, I suggest how the framework used for confidence intervals could easily be extended to derive confidence levels, or "tentative probabilities", for hypotheses. I also outline four quick methods for estimating these. This allows researchers to state their confidence in a hypothesis as a direct probability, instead of circuitously by p values referring to an unstated, hypothetical null hypothesis. The inevitable difficulties of statistical inference mean that these probabilities can only be tentative, but probabilities are the natural way to express uncertainties, so, arguably, researchers using statistical methods have an obligation to estimate how probable their hypotheses are by the best available method. Otherwise misinterpretations will fill the void. Key words: Confidence, Null hypothesis significance test, p value, Statistical inference
Large-scale multiple testing is a fundamental problem in high dimensional statistical inference. It is increasingly common that various types of auxiliary information, reflecting the structural relationship among the hypotheses, are available. Exploiting such auxiliary information can boost statistical power. To this end, we propose a framework based on a two-group mixture model with varying probabilities of being null for different hypotheses a priori, where a shape-constrained relationship is imposed between the auxiliary information and the prior probabilities of being null. An optimal reje…
Standard statistical methods that do not take proper account of the complexity of survey design can lead to erroneous inferences when applied to survey data due to unequal selection probabilities, clustering, and other design features. In particular, the actual type I error rates of tests of hypotheses using standard methods can be much bigger than the nominal significance level. Methods that take account of survey design features in testing hypotheses have been proposed, including Wald tests and quasi-score tests that involve the estimated covariance matrices of parameter estimates. In this p…
Nowadays, beta and Kumaraswamy distributions are the most popular models to fit continuous bounded data. These models present some characteristics in common and to select one of them in a practical situation can be of great interest. With this in mind, in this paper we propose a method of selection between the beta and Kumaraswamy distributions. We use the logarithm of the likelihood ratio statistic (denoted by $T_n$, where $n$ is the sample size) and obtain its asymptotic distribution under the hypotheses $H_{\mathcal B}$ and $H_{\mathcal K}$, where $H_{\mathcal B}$ ($H_{\mathcal K}$) denotes…
We analyze control of the familywise error rate (FWER) in a multiple testing scenario with a great many null hypotheses about the distribution of a high-dimensional random variable among which only a very small fraction are false, or "active". In order to improve power relative to conservative Bonferroni bounds, we explore a coarse-to-fine procedure adapted to a situation in which tests are partitioned into subsets, or "cells", and active hypotheses tend to cluster within cells. We develop procedures for a standard linear model with Gaussian data and a non-parametric case based on generalized …
Bayesian hypothesis testing is investigated when the prior probabilities of the hypotheses, taken as a random vector, are quantized. Nearest neighbor and centroid conditions are derived using mean Bayes risk error as a distortion measure for quantization. A high-resolution approximation to the distortion-rate function is also obtained. Human decision making in segregated populations is studied assuming Bayesian hypothesis testing with quantized priors.
The asymptotic efficiency of a generalized likelihood ratio test proposed by Cox is studied under the large deviations framework for error probabilities developed by Chernoff. In particular, two separate parametric families of hypotheses are considered [Cox, 1961, 1962]. The significance level is set such that the maximal type I and type II error probabilities for the generalized likelihood ratio test decay exponentially fast with the same rate. We derive the analytic form of such a rate that is also known as the Chernoff index [Chernoff, 1952], a relative efficiency measure when there is no p…
Statistical dependence between hypotheses poses a significant challenge to the stability of large scale multiple hypotheses testing. Ignoring it often results in an unacceptably large spread in the false positive proportion even though the average value is acceptable [21, 39, 40, 49]. However, the statistical dependence structure of data is often unknown. Using a generic signalprocessing model, Bayesian multiple testing, and simulations, we demonstrate that the variance of the false positive proportion can be substantially reduced even under unknown short range dependence. We do this by modeli…
Motivation: Combining the results of different experiments to exhibit complex patterns or to improve statistical power is a typical aim of data integration. The starting point of the statistical analysis often comes as sets of p-values resulting from previous analyses, that need to be combined in a flexible way to explore complex hypotheses, while guaranteeing a low proportion of false discoveries. Results: We introduce the generic concept of composed hypothesis, which corresponds to an arbitrary complex combination of simple hypotheses. We rephrase the problem of testing a composed hypothesis…
Multiple comparison procedures that control a family-wise error rate or false discovery rate provide an achieved error rate as the adjusted p-value for each hypothesis tested. However, since such p-values are not probabilities that the null hypotheses are true, empirical Bayes methods have been devised to estimate such posterior probabilities, called local false discovery rates (LFDRs) to emphasize the frequency interpretation of their priors. The main approaches to LFDR estimation, relying either on numerical algorithms to maximize likelihood or on the selection of smoothing parameters for no…
We consider the problem of statistical inference in a parametric finite Markov chain model and develop a robust estimator of the parameters defining the transition probabilities via minimization of a suitable (empirical) version of the popular density power divergence. Based on a long sequence of observations from a first-order stationary Markov chain, we have defined the minimum density power divergence estimator (MDPDE) of the underlying parameter and rigorously derived its asymptotic and robustness properties under appropriate conditions. Performance of the MDPDEs is illustrated theoretical…
Bayes factors represent the ratio of probabilities assigned to data by competing scientific hypotheses. Drawbacks of Bayes factors are their dependence on prior specifications that define null and alternative hypotheses and difficulties encountered in their computation. To address these problems, we define Bayes factor functions (BFF) directly from common test statistics. BFFs depend on a single non-centrality parameter that can be expressed as a function of standardized effect sizes, and plots of BFFs versus effect size provide informative summaries of hypothesis tests that can be easily aggr…
The paper addresses a joint sequential changepoint detection and identification/isolation problem for a general stochastic model, assuming that the observed data may be dependent and non-identically distributed, the prior distribution of the change point is arbitrary, and the post-change hypotheses are composite. The developed detection-identification theory generalizes the changepoint detection theory developed by Tartakovsky (2019) to the case of multiple composite post-change hypotheses when one has not only to detect a change as quickly as possible but also to identify (or isolate) the tru…
Statistical pragmatism embraces all efficient methods in statistical inference. Augmentation of the collected data is used herein to obtain representative population information from a large class of non-representative population's units. Parameter expansion of a probability model is shown to reduce the upper bound on the sum of error probabilities for a test of simple hypotheses, and a measure, R, is proposed for the effect of activating additional component(s) in the sufficient statistic.
This article explains, and discusses the merits of, three approaches for analyzing the certainty with which statistical results can be extrapolated beyond the data gathered. Sometimes it may be possible to use more than one of these approaches. (1) If there is an exact null hypothesis which is credible and interesting (usually not the case), researchers should cite a p value (significance level), although jargon is best avoided. (2) If the research result is a numerical value, researchers should cite a confidence interval. (3) If there are one or more hypotheses of interest, it may be possible…
Neyman and Pearson's theory of testing hypotheses does not warrant minimal epistemic reliability: the feature of driving to true conclusions more often than to false ones. The theory does not protect from the possible negative effects of the pragmatic value-laden unequal setting of error probabilities on the theory's epistemic reliability. Most importantly, in the case of a negative impact, no methodological adjustment is available to neutralize it, so in such cases, the discussed pragmatic-value-ladenness of the theory inevitably compromises the goal of attaining truth.
Bayesian hypothesis testing and minimax hypothesis testing represent extreme instances of detection in which the prior probabilities of the hypotheses are either completely and precisely known, or are completely unknown. Group minimax, also known as Gamma-minimax, is a robust intermediary between Bayesian and minimax hypothesis testing that allows for coarse or partial advance knowledge of the hypothesis priors by using information on sets in which the prior lies. Existing work on group minimax, however, does not consider the question of how to define the sets or groups of priors; it is assume…
The null hypothesis test (NHT) is widely used for validating scientific hypotheses but is actually highly criticized. Although Bayesian tests overcome several criticisms, some limits remain. We propose a Bayesian two-interval test (2IT) in which two hypotheses on an effect being present or absent are expressed as prespecified joint or disjoint intervals and their posterior probabilities are computed. The same formalism can be applied for superiority, non-inferiority, or equivalence tests. The 2IT was studied for three real examples and three sets of simulations (comparison of a proportion and …
The $γ$-FDP and $k$-FWER multiple testing error metrics, which are tail probabilities of the respective error statistics, have become popular recently as less-stringent alternatives to the FDR and FWER. We propose general and flexible stepup and stepdown procedures for testing multiple hypotheses about sequential (or streaming) data that simultaneously control both the type I and II versions of $γ$-FDP, or $k$-FWER. The error control holds regardless of the dependence between data streams, which may be of arbitrary size and shape. All that is needed is a test statistic for each data stream tha…
School of Mathematical and Computer Sciences, Heriot-Watt University（赫瑞斯泰学院数学与计算机科学系，赫瑞瓦特大学）；School of Mathematics, University of Edinburgh（爱丁堡大学数学学院）；Maxwell Institute for Mathematical Sciences（麦克斯韦数学科学研究所）
Under some mild Markov assumptions it is shown that the problem of designing optimal sequential tests for two simple hypotheses can be formulated as a linear program. The result is derived by investigating the Lagrangian dual of the sequential testing problem, which is an unconstrained optimal stopping problem, depending on two unknown Lagrangian multipliers. It is shown that the derivative of the optimal cost function with respect to these multipliers coincides with the error probabilities of the corresponding sequential test. This property is used to formulate an optimization problem that is…
Suppose you are told that taking a statin will reduce your risk of a heart attack or stroke by 3% in the next ten years, or that women have better emotional intelligence than men. You may wonder how accurate the 3% is, or how confident we should be about the assertion about women's emotional intelligence, bearing in mind that these conclusions are only based on samples of data? My aim here is to present two statistical approaches to questions like these. Approach 1 is often called null hypothesis testing but I prefer the phrase "baseline hypothesis": this is the standard approach in many areas…
We consider the problem of sequentially testing a simple null hypothesis versus a composite alternative hypothesis that consists of a finite set of densities. We study sequential tests that are based on thresholding of mixture-based likelihood ratio statistics and weighted generalized likelihood ratio statistics. It is shown that both sequential tests have several asymptotic optimality properties as error probabilities go to zero. First, for any weights, they minimize the expected sample size within a constant term under every scenario in the alternative hypothesis and at least to first order …
A new computation method of frequentist $p$-values and Bayesian posterior probabilities based on the bootstrap probability is discussed for the multivariate normal model with unknown expectation parameter vector. The null hypothesis is represented as an arbitrary-shaped region. We introduce new parametric models for the scaling-law of bootstrap probability so that the multiscale bootstrap method, which was designed for one-sided test, can also computes confidence measures of two-sided test, extending applicability to a wider class of hypotheses. Parameter estimation is improved by the two-step…
