生物分子复合物低剂量成像的可调谐安培相位板
Tunable Ampere phase plate for low dose imaging of biomolecular complexes
摘要：
介绍了一种可用于弱散射样品透射电子显微术的无支撑可调谐位相板装置。该装置依赖于由一段载流导线的磁场产生的受控相移，该载流导线的取向与电子束平行或反平行。的概念的有效性建立使用实验电子全息测量和安培定律的基础上的理论模型。计算机模拟被用来说明生物细胞和大分子研究的对比度增强。
英文摘要：
A novel device that can be used as a tunable support-free phase plate for transmission electron microscopy of weakly scattering specimens is described. The device relies on the generation of a controlled phase shift by the magnetic field of a segment of current-carrying wire that is oriented parallel or antiparallel to the electron beam. The validity of the concept is established using both experimental electron holographic measurements and a theoretical model based on Ampere's law. Computer simulations are used to illustrate the resulting contrast enhancement for studies of biological cells and macromolecules.
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