不同铁负载量下磁性铁蛋白结构的SANS对比变化研究
SANS contrast variation study of magnetoferritin structure at various iron loading
摘要：
磁性铁蛋白是一种人工合成的铁储存蛋白-铁蛋白的衍生物，已经合成了不同氧化铁负载值。利用中子小角散射实验研究了磁铁蛋白溶液的结构。较高的铁负载量导致了磁铁蛋白的中子散射长度密度的增加，也增加了复合物的多分散性。铁负载后的磁性核心的形成和蛋白质壳结构的变化的结论。
英文摘要：
Magnetoferritin, a synthetic derivate of iron storage protein - ferritin, has been synthesized with different iron oxide loading values. Small-angle neutron scattering experiments were applied to study the structure of magnetoferritin solutions using contrast variation method by varying the light to heavy water ratio of the solvent. Higher iron loading leads to increasing of the neutron scattering length density of magnetoferritin and also to the increase of the polydispersity of complexes. The formation of the magnetic core and the variation of the protein shell structure upon iron loading are concluded.
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