振荡、旋转和迁移细胞自发极化和边缘活动的极小模型
A minimal model for spontaneous cell polarization and edge activity in oscillating, rotating and migrating cells
摘要：
细胞如何打破对称性并组织其边缘活动进行定向运动是细胞生物学中的一个基本问题。细胞运动的物理模型通常依赖于调节因子的梯度和/或来自运动本身的反馈来描述边缘活动的极化。然而，这些方法无法解释极化开始之前的细胞行为。我们的分析使用的模型系统的极化和移动的鱼表皮角质细胞提出了一种新的和简单的原则，自组织的细胞活动中，局部细胞边缘的动态依赖于距离细胞中心，但不是相对于前后轴的方向。我们验证了这一原则与随机模型，忠实地再现了一系列的细胞迁移行为。我们的研究结果表明，自发极化，持续的运动，和细胞的形状是新兴的本地细胞边缘的动力学控制的距离，从细胞中心的属性。
英文摘要：
How the cells break symmetry and organize their edge activity to move directionally is a fun- damental question in cell biology. Physical models of cell motility commonly rely on gradients of regulatory factors and/or feedback from the motion itself to describe polarization of edge activity. Theses approaches, however, fail to explain cell behavior prior to the onset of polarization. Our analysis using the model system of polarizing and moving fish epidermal keratocytes suggests a novel and simple principle of self-organization of cell activity in which local cell-edge dynamics depends on the distance from the cell center, but not on the orientation with respect to the front-back axis. We validate this principle with a stochastic model that faithfully reproduces a range of cell-migration behaviors. Our findings indicate that spontaneous polarization, persistent motion, and cell shape are emergent properties of the local cell-edge dynamics controlled by the distance from the cell center.
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