绘制沃丁顿景观，捕捉动态表观遗传学
Drawing a Waddington landscape to capture dynamic epigenetics
摘要：
表观遗传学在目前的文献中最常被简化为染色质标记，而这个概念最初是在更一般的背景下定义的。这种狭隘的观点忽略了表观遗传记忆实际上在生命系统中通过具有永久分子更新的稳态机制更有力地确保。这种误解很可能是由于误导性的直觉和传统和定量生物学家之间的对话不足。为了揭开动态表观遗传学的神秘面纱，它最著名的形象，沃丁顿景观及其吸引力，明确绘制。所提供的简单例子足以突出动态基因网络的主要要求和特征，潜在的细胞分化、去分化和转分化。
英文摘要：
Epigenetics is most often reduced to chromatin marking in the current literature, whereas this notion was initially defined in a more general context. This restricted view ignores that epigenetic memories are in fact more robustly ensured in living systems by steady state mechanisms with permanent molecule renewal. This misconception is likely to result from misleading intuitions and insufficient dialogues between traditional and quantitative biologists. To demystify dynamic epigenetics, its most famous image, a Waddington landscape and its attractors, are explicitly drawn. The simple example provided is sufficient to highlight the main requirements and characteristics of dynamic gene networks, underlying cellular differentiation, de-differentiation and trans-differentiation.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
