规范语义网络支持慢性卒中后失语症的残余语言功能
The canonical semantic network supports residual language function in chronic post-stroke aphasia
摘要：
目前中风后语言恢复的理论受到小型研究的限制。在这里，我们的目标是测试当前理论的预测，并解决右半球对长期恢复的贡献的不一致性。我们首先在43名健康对照者中定义了规范语义网络。然后，在一组43例慢性卒中后失语症患者中，我们测试了该网络中的活动是否预测了语义理解，命名和流畅性的测量结果，同时控制了病变体积效应。典型网络激活占语言测试成绩方差的22-33%。全脑分析证实了这些发现，并揭示了一组核心区域显示出与所有语言测量的积极关系。接下来，我们评估了网络的左右半球部分的激活幅度之间的关系，以及右半球激活与左半球损伤程度之间的关系。在每个半球网络的激活幅度是密切相关的，但四个右额叶区域显示出高活性的患者与大型病变。其中两个区域（额下回盖部和辅助运动区）的活动与较大病变患者的语言能力较好相关，但与较小病变患者的语言能力较差相关。我们的研究结果表明，双侧语言网络支持中风后的语言处理，与广泛的左半球损伤相关的右半球激活发生在典型的语义网络之外，并根据左半球损伤的程度不同，对它们与行为的关系做出不同的贡献
英文摘要：
Current theories of language recovery after stroke are limited by a reliance on small studies. Here, we aimed to test predictions of current theory and resolve inconsistencies regarding right hemispheric contributions to long-term recovery. We first defined the canonical semantic network in 43 healthy controls. Then, in a group of 43 patients with chronic post-stroke aphasia, we tested whether activity in this network predicted performance on measures of semantic comprehension, naming, and fluency while controlling for lesion volume effects. Canonical network activation accounted for 22-33% of the variance in language test scores. Whole-brain analyses corroborated these findings, and revealed a core set of regions showing positive relationships to all language measures. We next evaluated the relationship between activation magnitudes in left and right hemispheric portions of the network, and how right hemispheric activation related to the extent of left hemispheric damage. Activation magnitudes in the each hemispheric network were strongly correlated, but four right frontal regions showed heightened activity in patients with large lesions. Activity in two of these regions (inferior frontal gyrus pars opercularis and supplementary motor area) was associated with better language abilities in patients with larger lesions, but poorer language abilities in patients with smaller lesions. Our results indicate that bilateral language networks support language processing after stroke, and that right hemispheric activations related to extensive left hemisphere damage occur outside of the canonical semantic network and differentially contribute to in their relationship to behavior depending on the extent of left hemispheric damage
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
