CRKL在乳腺癌转移中的作用：来自系统生物学的观点
The role of CRKL in Breast Cancer Metastasis: Insights from Systems Biology
摘要：
microRNAs（miRNAs）是一类在转录后调控基因表达的非编码小分子RNA。它们参与关键的生物学过程，然后可能在包括癌症在内的人类疾病的发展中发挥重要作用，特别是它们参与乳腺癌转移已被证实。最近，作者的参考。（\cite{key1}已经发现miR-429可能在抑制乳腺癌转移中起作用，并且已经将其靶基因CRKL鉴定为潜在候选基因。本文利用系统生物学工具研究CRKL参与ERK 1/2信号通路的正向调节，并通过拓扑学上的前馈环参与LYN的调节。
英文摘要：
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally. They are involved in key biological processes and then may play a major role in the development of human diseases including cancer, in particular their involvement in breast cancer metastasis has been confirmed. Recently, the authors of ref.(\cite{key1} have found that miR-429 may have a role in the inhibition of breast cancer metastasis and have identified its target gene CRKL as a potential candidate. In this paper, by using systems biology tools we have shown that CRKL is involved in positive regulation of ERK1/2 signaling pathway and contribute to the regulation of LYN through a topological generalization of feed forward loop.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
