用于非均匀环境的快速机械映射的螺旋纳米机器
Helical Nanomachines for Fast Mechanical Mapping of Heterogeneous Environments
摘要：
人造微和纳米机器已经被设想和证明是各种应用的潜在候选者，范围从靶向药物或基因递送、细胞操纵、环境传感等等。在这里，我们展示了螺旋纳米机器的应用，可以测量和映射复杂的非均匀环境的局部流变特性。使用磁场精确控制螺旋纳米机器的位置，而瞬时取向提供了具有高空间和时间精度的周围介质粘度的估计。除了在具有剪切速率独立粘度的纯粘性和粘弹性介质（Boger流体）中提供粘度估计之外，还发现它们的运动对流体弹性极其敏感。总之，我们报告了一个很有前途的新技术，映射的流变特性的复杂的流体环境的螺旋纳米机器具有高的空间和时间分辨率，功能，超越了现有的被动和主动微流变方法的能力。
英文摘要：
Artificial micro and nano machines have been envisioned and demonstrated as potential candidates for variety of applications, ranging from targeted drug or gene delivery, cell manipulation, environmental sensing and many more. Here, we demonstrate the application of helical nanomachines that can measure and map the local rheological properties of a complex heterogeneous environment. The position of the helical nanomachine was controlled precisely using magnetic fields, while the instantaneous orientation provided an estimation of the viscosity of the surrounding medium with high spatial and temporal accuracy. Apart from providing viscosity estimates in purely viscous and viscoelastic media with shear rate independent viscosity (Boger fluids), their motion was also found to be extremely sensitive to fluid elasticity. Taken together we report a promising new technique of mapping the rheological properties of a complex fluidic environment by helical nanomachines with high spatial and temporal resolutions, a functionality that goes beyond the capabilities of existing passive and active microrheological methods.
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