与神经元接口的电解质门控有机突触晶体管
Electrolyte-gated organic synapse transistor interfaced with neurons
摘要：
我们展示了一种电解质门控混合纳米颗粒/有机突触（突触晶体管，称为EGOS），表现出短期可塑性的生物突触。EGOS的反应使其适合与神经元连接：在低至50 mV的尖峰电压（与神经元中动作电位的幅度相当）下观察到短期可塑性，并且典型的反应时间在数十毫秒的范围内。人神经母细胞瘤干细胞在EGOS上粘附并分化为神经元。我们观察到细胞的存在不会改变装置的短期可塑性。
英文摘要：
We demonstrate an electrolyte-gated hybrid nanoparticle/organic synapstor (synapse-transistor, termed EGOS) that exhibits short-term plasticity as biological synapses. The response of EGOS makes it suitable to be interfaced with neurons: short-term plasticity is observed at spike voltage as low as 50 mV (in a par with the amplitude of action potential in neurons) and with a typical response time in the range of tens milliseconds. Human neuroblastoma stem cells are adhered and differentiated into neurons on top of EGOS. We observe that the presence of the cells does not alter short-term plasticity of the device.
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