从细胞到系统的自生思维的神经生物学：整合来自病变研究、人类颅内电生理学、神经化学和神经内分泌学的证据
The neurobiology of self-generated thought from cells to systems: Integrating evidence from lesion studies, human intracranial electrophysiology, neurochemistry, and neuroendocrinology
摘要：
对自我生成思维的神经基础的研究已经超越了简单地识别默认网络激活，而是朝着更全面的观点发展，认识到额顶叶控制网络和其他区域的作用。未来的一项主要任务是揭示在自我生成思维过程中广泛分布的大脑区域的功能角色和时间动态。我们认为，其他各种神经科学方法-包括病变研究，人类颅内电生理学，神经化学的操纵-有很大的贡献，这个项目。然而，这些不同的数据还有待于与从神经成像中获得的对自我生成思维的日益增长的理解相结合。在这里，我们强调了几个正在进行的调查领域，并说明了其他方法的证据如何证实，补充和澄清功能神经影像学的发现。每一种方法都有其独特的优势：功能性神经成像揭示了许多关于大脑区域和网络的多样性。损伤研究指出了对产生和有意识地体验自我产生的思想至关重要的区域。人类颅内电生理学阐明了大脑中思想是如何产生的，在哪里产生的，以及这种活动随后传播到哪里。最后，神经递质和激素水平的测量和操纵可以澄清什么样的神经化学环境驱动或促进自我生成的认知。整合来自多种互补模式的证据将是提高我们对自我生成思维的功能和功能障碍形式的神经生物学理解的关键一步。
英文摘要：
Investigation of the neural basis of self-generated thought is moving beyond a simple identification with default network activation toward a more comprehensive view recognizing the role of the frontoparietal control network and other areas. A major task ahead is to unravel the functional roles and temporal dynamics of the widely distributed brain regions recruited during self-generated thought. We argue that various other neuroscientific methods - including lesion studies, human intracranial electrophysiology, and manipulation of neurochemistry - have much to contribute to this project. These diverse data have yet to be synthesized with the growing understanding of self-generated thought gained from neuroimaging, however. Here, we highlight several areas of ongoing inquiry and illustrate how evidence from other methodologies corroborates, complements, and clarifies findings from functional neuroimaging. Each methodology has particular strengths: functional neuroimaging reveals much about the variety of brain areas and networks reliably recruited. Lesion studies point to regions critical to generating and consciously experiencing self-generated thought. Human intracranial electrophysiology illuminates how and where in the brain thought is generated and where this activity subsequently spreads. Finally, measurement and manipulation of neurotransmitter and hormone levels can clarify what kind of neurochemical milieu drives or facilitates self-generated cognition. Integrating evidence from multiple complementary modalities will be a critical step on the way to improving our understanding of the neurobiology of functional and dysfunctional forms of self-generated thought.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
