手征性改变了纽结之间的相互作用
Chirality modifies the interaction between knots
摘要：
在这项研究中，我们考虑了一个理想化的典型的光镊实验，涉及一个半柔性的双打结聚合物，与空间位阻和持久性长度匹配的dsDNA在高盐浓度，在强拉伸。使用详尽的分子动力学模拟，我们表明，不仅没有一个双打结的双链DNA丝张力下拥有一个自由能最小值时，两个结是交织在一起，而且，这个最小值的深度取决于两个结的相对手性。我们合理化这种依赖的有效相互作用的手性链熵和弯曲能之间的竞争。
英文摘要：
In this study we consider an idealization of a typical optical tweezers experiment involving a semiflexible double-knotted polymer, with steric hindrance and persistence length matching those of dsDNA in high salt concentration, under strong stretching. Using exhaustive Molecular Dynamics simulations we show that not only does a double-knotted dsDNA filament under tension possess a free energy minimum when the two knots are intertwined, but also that the depth of this minimum depends on the relative chirality of the two knots. We rationalize this dependence of the effective interaction on the chirality in terms of a competition between chain entropy and bending energy.
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