竞争多价粒子的开关状表面结合
Switch-like surface binding of competing multivalent particles
摘要：
多价颗粒竞争结合在同一表面上可以表现出开关样行为，这取决于表面上受体的浓度。当受体浓度低时，能量主导结合的自由能，并且具有少量强结合配体的颗粒优先结合到表面。在较高的受体浓度，多价效应变得显着，熵占主导地位的结合自由能;粒子有许多弱结合配体优先结合到表面。在这两种状态之间有一个“转换点”，在这个点上，表面对两种粒子的结合强度相等。我们证明了一个简单的理论可以解释这种开关式的行为，并提出了支持理论预测的数值计算。我们认为，结合选择性的基础上受体密度，而不是身份，可能有实际应用。
英文摘要：
Multivalent particles competing for binding on the same surface can exhibit switch-like behaviour, depending on the concentration of receptors on the surface. When the receptor concentration is low, energy dominates the free energy of binding, and particles having a small number of strongly-binding ligands preferentially bind to the surface. At higher receptor concentrations, multivalent effects become significant, and entropy dominates the binding free energy; particles having many weakly-binding ligands preferentially bind to the surface. Between these two regimes there is a "switch-point", at which the surface binds the two species of particles equally strongly. We demonstrate that a simple theory can account for this switch-like behaviour and present numerical calculations that support the theoretical predictions. We argue that binding selectivity based on receptor density, rather than identity, may have practical applications.
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