metaSPAdes:一种新的通用从头宏基因组学组装器
metaSPAdes: a new versatile de novo metagenomics assembler
摘要:
虽然宏基因组学已经成为分析细菌种群的首选技术,但宏基因组数据的组装仍然很困难,从而扼杀了生物学发现。MetaSPAdes是一个新的组装器,它解决了宏基因组分析的挑战,并利用了被证明在单细胞和高度多态性二倍体基因组组装中有用的计算思想。我们基准MetaSPAdes对其他国家的最先进的宏基因组组装在不同的数据集,并证明它的结果在高质量的组件。
英文摘要:
While metagenomics has emerged as a technology of choice for analyzing bacterial populations, assembly of metagenomic data remains difficult thus stifling biological discoveries. metaSPAdes is a new assembler that addresses the challenge of metagenome analysis and capitalizes on computational ideas that proved to be useful in assemblies of single cells and highly polymorphic diploid genomes. We benchmark metaSPAdes against other state-of-the-art metagenome assemblers across diverse da-tasets and demonstrate that it results in high-quality assemblies.
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