囊泡粘附揭示了生物物理表征的新的普遍关系
Vesicle adhesion reveals novel universal relationships for biophysical characterization
摘要：
粘附在从细胞运输到组织发育的各种生物功能中起着不可或缺的作用。因此，粘附强度的估计对于获得对这些现象的生物物理洞察变得重要。在这封信中，我们使用曲率弹性来呈现非直观的，但非常简单的，普遍的关系，捕获囊泡-底物相互作用。我们的研究表明，相反的高度，指数的接触面积，和所需的力从基板上分离的囊泡的粘附能的平方根线性变化。这些关系不仅提供了有效的策略，梳理出生物分子的粘附能，但也可以用来表征弹性仿生纳米粒子的物理性能。我们验证了建模预测与实验数据从以前的两项研究。
英文摘要：
Adhesion plays an integral role in diverse biological functions ranging from cellular transport to tissue development. Estimation of adhesion strength, therefore, becomes important to gain biophysical insight into these phenomena. In this Letter, we use curvature elasticity to present non-intuitive, yet remarkably simple, universal relationships that capture vesicle-substrate interactions. Our study reveals that the inverse of the height, exponential of the contact area, and the force required to detach the vesicle from the substrate vary linearly with the square root of the adhesion energy. These relationships not only provide efficient strategies to tease out adhesion energy of biological molecules but can also be used to characterize the physical properties of elastic biomimetic nanoparticles. We validate the modeling predictions with experimental data from two previous studies.
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