核酸外切酶缺陷型DNA聚合酶的动力学和热力学
Kinetics and thermodynamics of exonuclease-deficient DNA polymerases
摘要：
外切核酸酶缺陷的DNA聚合酶的动力学理论的基础上，实验观察到的速率不仅取决于新纳入的核苷酸，但也对以前的，导致从伯努利模板的马尔可夫DNA序列的增长。核苷酸浓度和模板序列的依赖性明确考虑。在这个框架中，DNA复制的动力学和热力学性质，特别是平均增长速度，错误概率，和熵产生的速率常数和浓度的解析计算。T7病毒和人类线粒体的DNA聚合酶的理论与数值模拟进行了比较。
英文摘要：
A kinetic theory is developed for exonuclease-deficient DNA polymerases, based on the experimental observation that the rates depend not only on the newly incorporated nucleotide, but also on the previous one, leading to the growth of Markovian DNA sequences from a Bernoullian template. The dependences on nucleotide concentrations and template sequence are explicitly taken into account. In this framework, the kinetic and thermodynamic properties of DNA replication, in particular, the mean growth velocity, the error probability, and the entropy production in terms of the rate constants and the concentrations are calculated analytically. Theory is compared with numerical simulations for the DNA polymerases of T7 viruses and human mitochondria.
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