癌症生物治疗资源
A Cancer Biotherapy Resource
摘要：
癌症生物治疗（CB），相对于癌症化疗，是使用大分子生物制剂而不是有机化学品或药物来治疗癌症。生物制剂通常比化学制剂具有更高的选择性和更小的毒副作用。国际贸易促进委员会，作为CB的唯一主要信息数据库，似乎缺乏各种癌症生物治疗方案的一些关键信息。因此，有必要建立一个全面的CB数据库。该数据库可供癌症患者使用，也应该成为癌症研究人员科学思想的共鸣板。数据库/网络服务器具有关于迄今为止的癌症生物治疗方案的主要家族的信息，即蛋白激酶抑制剂、Ras途径抑制剂、细胞周期活性剂、MAb（单克隆抗体）、ADEPT（抗体导向酶前药疗法）、细胞因子、抗血管生成剂、癌症疫苗、基于细胞的免疫治疗剂、基因疗法、造血生长因子、类维生素A和CAAT。对于每种生物治疗方案，我们将在填充数据库时提取以下属性：癌症类型，涉及的基因和基因产物，基因序列，受影响的器官，参考文献，临床分期/阶段，生存率，临床测试中心位置，成本，患者博客，研究人员博客和未来的工作。该数据库将通过一个网站向公众开放，并提供常见问题解答，使外行人能够理解，并提供讨论页面，供研究人员表达他们的观点和想法。除了有关生物治疗方案的信息外，该网站还将链接到其他具有生物学意义的数据库，如结构蛋白质组学，代谢组学，糖组学和脂质组学数据库，以及世界各地有关癌症治疗结果的新闻。数据库的属性将定期更新，以便在发现新的属性时予以更新。
英文摘要：
Cancer Biotherapy (CB), as opposed to cancer chemotherapy, is the use of macromolecular, biological agents instead of organic chemicals or drugs to treat cancer. Biological agents usually have higher selectivity and have less toxic side effects than chemical agents. The I.S.B.T.C., being the only major information database for CB, seems lacking in some crucial information on various cancer biotherapy regimens. It is thus necessary to have a comprehensive curated CB database. The database accessible to cancer patients and also should be a sounding board for scientific ideas by cancer researchers. The database/web server has information about main families of cancer biotherapy regimens to date, namely, Protein Kinase Inhibitors, Ras Pathway Inhibitors, Cell-Cycle Active Agents, MAbs (monoclonal antibodies), ADEPT (Antibody-Directed Enzyme Pro-Drug Therapy), Cytokines, Anti-Angiogenesis Agents, Cancer Vaccines, Cell-based Immunotherapeutics, Gene Therapy, Hematopoietic Growth Factors, Retinoids, and CAAT. For each biotherapy regimen, we will extract the following attributes in populating the database: Cancer type, Gene/s and gene product/s involved, Gene sequence, Organs affected, Reference papers, Clinical phase/stage, Survival rate, Clinical test center locations, Cost, Patient blogs, Researcher blogs, and Future work. The database will be accessible to public through a website and had FAQs for making it understandable to the laymen and discussion page for researchers to express their views and ideas. In addition to information about the biotherapy regimens, the website will link to other biologically significant databases like structural proteomics, metabolomics, glycomics, and lipidomics databases, as well as to news around the world regarding cancer therapy results. The database attributes would be regularly updated for novel attributes as discoveries are made.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
