细胞自主性的分子水平调整控制着细胞群体的集体行为
Molecular-level tuning of cellular autonomy controls the collective behaviors of cell populations
摘要：
要严格理解多细胞行为是如何从单细胞的行为中产生的，需要定量框架来弥合遗传电路、细胞在空间中的排列和群体水平行为之间的差距。在这里，我们提供了这样一个框架的一个无处不在的类多细胞系统-即“分泌和感觉细胞”，通过分泌和感知信号分子进行通信。通过使用正式的，数学的参数，并引入表型图的概念，我们展示了这些细胞如何调整其自主和集体行为的程度，以实现不同的单细胞和群体水平的表型;这些现象有生物学上的类似物，如群体感应或旁分泌信号。我们还定义了“人口熵”，一个测量的数量的安排，人口的细胞可以假设，并演示如何减少人口的熵伴随着有序的空间格局的形成。我们的概念框架将不同的系统（包括组织和微生物）与共同的原则联系在一起。
英文摘要：
A rigorous understanding of how multicellular behaviors arise from the actions of single cells requires quantitative frameworks that bridge the gap between genetic circuits, the arrangement of cells in space, and population-level behaviors. Here, we provide such a framework for a ubiquitous class of multicellular systems - namely, "secrete-and-sense cells" that communicate by secreting and sensing a signaling molecule. By using formal, mathematical arguments and introducing the concept of a phenotype diagram, we show how these cells tune their degrees of autonomous and collective behavior to realize distinct single-cell and population-level phenotypes; these phenomena have biological analogs, such as quorum sensing or paracrine signaling. We also define the "entropy of population," a measurement of the number of arrangements that a population of cells can assume, and demonstrate how a decrease in the entropy of population accompanies the formation of ordered spatial patterns. Our conceptual framework ties together diverse systems, including tissues and microbes, with common principles.
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