Coinami：一种以DNA序列比对作为工作量证明的加密货币
Coinami: A Cryptocurrency with DNA Sequence Alignment as Proof-of-work
摘要：
使用高通量测序（HTS）平台生成的数据量的增长率现在超过了摩尔定律所规定的增长。预计在2025年之前，HTS数据将超过其他“大数据”领域，如天文学。除了用于研究目的的基因组测序外，临床环境中的基因组和外显子组测序将成为医疗保健的常规部分。然而，分析如此大量的数据并非没有计算挑战。由于参考基因组的定期更新，这一负担甚至更加增加，这通常需要重新分析现有数据。在这里，我们提出了硬币应用中介接口（Coinami）分配工作量的映射读取参考基因组使用志愿者网格计算机的方法类似于伯克利开放式网络计算基础设施（BOINC）。然而，由于HTS读码映射需要大量的计算资源，并且需要快速的分析投票率，Coinami使用HTS读码映射作为工作证明来生成有效的区块来管理自己的加密货币系统，这可能有助于激励志愿者投入更多的资源。Coinami协议包括确保志愿者执行的工作正确的机制，并提供基因组数据隐私。Coinami的原型实现可在http://coinami.github.io/上获得。
英文摘要：
Rate of growth of the amount of data generated using the high throughput sequencing (HTS) platforms now exceeds the growth stipulated by Moore's Law. The HTS data is expected to surpass those of other "big data" domains such as astronomy, before the year 2025. In addition to sequencing genomes for research purposes, genome and exome sequencing in clinical settings will be a routine part of health care. The analysis of such large amounts of data, however, is not without computational challenges. This burden is even more increased due to the periodic updates to reference genomes, which typically require re-analysis of existing data. Here we propose Coin-Application Mediator Interface (Coinami) to distribute the workload for mapping reads to reference genomes using a volunteer grid computer approach similar to Berkeley Open Infrastructure for Network Computing (BOINC). However, since HTS read mapping requires substantial computational resources and fast analysis turnout is desired, Coinami uses the HTS read mapping as proof-of-work to generate valid blocks to main its own cryptocurrency system, which may help motivate volunteers to dedicate more resources. The Coinami protocol includes mechanisms to ensure that jobs performed by volunteers are correct, and provides genomic data privacy. The prototype implementation of Coinami is available at http://coinami.github.io/.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
