大鼠肠系膜小动脉平滑肌细胞固有节律的本征系统模型
Inherent rhythm of smooth muscle cells in rat mesenteric arterioles: an eigensystem formulation
摘要：
在文献中的实验数据和数学方程的基础上，我们重塑平滑肌细胞（SMCs）的离子动力学作为一个本征系统制定，这是有效的调查有限的变量从平衡像在常见的实验操作变化。该算法从频域分析提供了另一种观点，并使人们能够通过共振相关机制来探测SMC节律的功能。数值结果显示，肠系膜小动脉中SMC的钙振荡有三种类型：自发性钙振荡、激动剂依赖性钙振荡和激动剂依赖性钙峰。对于简单的单和双SMC，我们证明了与钙振荡相关的复杂信号之间的同步特性，并显示了各种同步和共振条件下钙和电压信号之间的不同相关关系。对于实际的细胞簇，我们的分析表明，SMC的节律可以（1）有利于增强远程细胞之间的信号通信，（2）响应于针对触发全局振荡模式的瞬时刺激的显著钙峰，以及（3）通过跨越不均匀SMC的蛙跳（非分子扩散）钙波来表征全局振荡模式。
英文摘要：
On the basis of experimental data and mathematical equations in the literature, we remodel the ionic dynamics of smooth muscle cells (SMCs) as an eigensystem formulation, which is valid for investigating finite variations of variables from the equilibrium like in common experimental operations. This algorithm provides an alternate viewpoint from frequency-domain analysis and enables one to probe functionalities of SMC's rhythm by means of a resonance-related mechanism. Numerical results show three types of calcium oscillations of SMCs in mesenteric arterioles: spontaneous calcium oscillation, agonist-dependent calcium oscillation, and agonist-dependent calcium spike. For simple single and double SMCs, we demonstrate properties of synchronization among complex signals related to calcium oscillations, and show different correlation relations between calcium and voltage signals for various synchronization and resonance conditions. For practical cell clusters, our analyses indicate that the rhythm of SMCs could (1) benefit enhancements of signal communications among remote cells, (2) respond to a significant calcium peaking against transient stimulations for triggering globally-oscillating modes, and (3) characterize the globally-oscillating modes via frog-leap (non-molecular-diffusion) calcium waves across inhomogeneous SMCs.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
