电穿孔经皮药物输送:多层方法
Iontophoretic transdermal drug delivery: a multi-layered approach
AI总结:
本文提出多层数学模型,描述离子渗透系统经皮药物释放过程,结合Nernst-Planck方程与拉普拉斯方程,分析稳定性并采用有限差分法求解。
摘要:
我们提出一个多层数学模型,用于描述离子渗透系统经皮药物释放过程。Nernst-Planck方程描述基本的对流扩散过程,电势由拉普拉斯方程获得。这些方程在多域中补充了合适的界面和边界条件。在不同场景下讨论了数学问题的稳定性,并采用有限差分法求解耦合系统。包括数值实验以展示不同条件下药物动力学行为。
英文摘要:
We present a multi-layer mathematical model to describe the the transdermal drug release from an iontophoretic system. The Nernst-Planck equation describe the basic convection-diffusion process, with the electric potential obtained by Laplace equation. These equations are complemented with suitable interface and boundary conditions in a multi-domain. The stability of the mathematical problem is discussed in different scenarios and a finite-difference method is used to solve the coupled system. Numerical experiments are included to illustrate the drug dynamics under different conditions.
机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。