CVD石墨烯通道FET生物传感器对DNA和聚赖氨酸的检测
Detection of DNA and Poly-L-Lysine using CVD Graphene-channel FET Biosensors
摘要：
利用石墨烯通道场效应生物传感器检测了双链DNA与聚赖氨酸的结合。传感器由CVD石墨烯组成，采用清洁、无蚀刻剂的转移方法转移。通过石墨烯晶体管的电导变化检测DNA和聚-l-赖氨酸的存在。在石墨烯通道暴露于含有DNA或聚-1-赖氨酸的溶液之后，观察到狄拉克电压（石墨烯电阻达到峰值的电压）的容易测量的偏移。狄拉克电压偏移归因于石墨烯表面上带电分子的结合/未结合。响应的极性随着聚-L-赖氨酸而改变为正方向，并且随着DNA而改变为负方向。该响应导致48.5kbp DNA的检测限为8 pM，聚-l-赖氨酸的检测限为11 pM。这种生物传感器制作简单，可重复使用，是一种很有前途的生物分子传感器
英文摘要：
A graphene channel field-effect biosensor is demonstrated for detecting the binding of double-stranded DNA and poly-l-lysine. Sensors consist of CVD graphene transferred using a clean, etchant-free transfer method. The presence of DNA and poly-l-lysine are detected by the conductance change of the graphene transistor. A readily measured shift in the Dirac Voltage (the voltage at which the graphenes resistance peaks) is observed after the graphene channel is exposed to solutions containing DNA or poly-l-lysine. The Dirac voltage shift is attributed to the binding/unbinding of charged molecules on the graphene surface. The polarity of the response changes to positive direction with poly-l-lysine and negative direction with DNA. This response results in detection limits of 8 pM for 48.5 kbp DNA and 11 pM for poly-l-lysine. The biosensors are easy to fabricate, reusable and are promising as sensors of a wide variety of charged biomolecules
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