噪声扩展了枯草芽孢杆菌感受态电路的响应范围
Noise expands the response range of the Bacillus subtilis competence circuit
摘要：
基因调控电路必须与由于有限数量的蛋白质而产生的内在噪音作斗争。一个突出的例子是枯草芽孢杆菌中的感受态回路，它在感受态事件持续期间表现出比执行相同功能的合成构建的类似物大得多的噪声。在这里，使用随机建模和荧光显微镜，我们表明，这种较大的噪声允许细胞退出终端表型状态，这扩大了细胞响应的应激水平的范围，并导致在群体水平上的表型异质性。这是一个重要的例子，说明噪音如何在遗传决策回路中赋予功能性益处。
英文摘要：
Gene regulatory circuits must contend with intrinsic noise that arises due to finite numbers of proteins. While some circuits act to reduce this noise, others appear to exploit it. A striking example is the competence circuit in Bacillus subtilis, which exhibits much larger noise in the duration of its competence events than a synthetically constructed analog that performs the same function. Here, using stochastic modeling and fluorescence microscopy, we show that this larger noise allows cells to exit terminal phenotypic states, which expands the range of stress levels to which cells are responsive and leads to phenotypic heterogeneity at the population level. This is an important example of how noise confers a functional benefit in a genetic decision-making circuit.
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