松质骨微结构的长程节点-支柱分析
Long range node-strut analysis of trabecular bone microarchitecture
摘要：
目的：我们提出了一种新的骨小梁微结构的形态测量，称为平均节点强度（NdStr），这是一个新开发的方法，称为远程节点支柱分析的一部分。我们的总体目标是描述和量化骨小梁网络的表观“格子状”微结构。方法：在某些方面类似于Garrahan等人介绍的拓扑节点-支柱分析[J. Microsc. 142，341-349（1986）]，我们的方法的特点在于强调长距离小梁连接。因此，虽然一个像素的拓扑分类（后tenonization）作为一个节点，支柱，或终端，可以确定从该像素的3x 3邻域，我们的方法，它不涉及tenonization，考虑到一个更大的邻域。此外，我们的方法不是将每个像素离散分类为节点、支柱或终点，而是产生连续变量节点强度。在感兴趣的区域上对节点强度进行平均以产生该区域的平均节点强度。结果：我们已经将我们的长程节点-支柱分析应用于一组26个高分辨率…使用传统的组织形态计量学对在与pQCT扫描相同的位置获得的骨活检进行计算Nd/Tm比值。结论：新引入的形态测量允许定量评估骨小梁的长程连接。该方法的一个优点是它基于可以从患者非侵入性地获得的pQCT图像，即，而不必从患者获得骨活检。
英文摘要：
Purpose: We present a new morphometric measure of trabecular bone microarchitecture, called mean node strength (NdStr), which is part of a newly developed approach called long range node-strut analysis. Our general aim is to describe and quantify the apparent "latticelike" microarchitecture of the trabecular bone network. Methods: Similar in some ways to the topological node-strut analysis introduced by Garrahan et al. [J. Microsc. 142, 341-349 (1986)], our method is distinguished by an emphasis on long-range trabecular connectivity. Thus, while the topological classification of a pixel (after skeletonization) as a node, strut, or terminus, can be determined from the 3x3 neighborhood of that pixel, our method, which does not involve skeletonization, takes into account a much larger neighborhood. In addition, rather than giving a discrete classification of each pixel as a node, strut, or terminus, our method produces a continuous variable, node strength. The node strength is averaged over a region of interest to produce the mean node strength of the region. Results: We have applied our long range node-strut analysis to a set of 26 high-resolution ... The Nd/Tm ratios were computed using traditional histomorphometry performed on bone biopsies obtained at the same location as the pQCT scans. Conclusions: The newly introduced morphometric measure allows a quantitative assessment of the long-range connectivity of trabecular bone. One advantage of this method is that it is based on pQCT images that can be obtained noninvasively from patients, i.e., without having to obtain a bone biopsy from the patient.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
