Linear Mixed Models (LMMs) are important tools in statistical genetics. When used for feature selection, they allow to find a sparse set of genetic traits that best predict a continuous phenotype of interest, while simultaneously correcting for various confounding factors such as age, ethnicity and population structure. Formulated as models for linear regression, LMMs have been restricted to continuous phenotypes. We introduce the Sparse Probit Linear Mixed Model (Probit-LMM), where we generalize the LMM modeling paradigm to binary phenotypes. As a technical challenge, the model no longer possesses a closed-form likelihood function. In this paper, we present a scalable approximate inference algorithm that lets us fit the model to high-dimensional data sets. We show on three real-world examples from different domains that in the setup of binary labels, our algorithm leads to better prediction accuracies and also selects features which show less correlation with the confounding factors.
In this paper, we study the problem of sparse mixed linear regression on an unlabeled dataset that is generated from linear measurements from two different regression parameter vectors. Since the data is unlabeled, our task is not only to figure out a good approximation of the regression parameter vectors but also to label the dataset correctly. In its original form, this problem is NP-hard. The most popular algorithms to solve this problem (such as Expectation-Maximization) have a tendency to stuck at local minima. We provide a novel invex relaxation for this intractable problem which leads t…
Facebook Inc.（Facebook公司）；Penn State University（宾夕法尼亚州立大学）；Texas Tech University（德克萨斯理工大学）
In this paper, we propose a convex formulation for learning logistic regression model (logit) with latent heterogeneous effect on sub-population. In transportation, logistic regression and its variants are often interpreted as discrete choice models under utility theory (McFadden, 2001). Two prominent applications of logit models in the transportation domain are traffic accident analysis and choice modeling. In these applications, researchers often want to understand and capture the individual variation under the same accident or choice scenario. The mixed effect logistic regression (mixed log…
Theoretical results show that Bayesian methods can achieve lower bounds on regret for online logistic regression. In practice, however, such techniques may not be feasible especially for very large feature sets. Various approximations that, for huge sparse feature sets, diminish the theoretical advantages, must be used. Often, they apply stochastic gradient methods with hyper-parameters that must be tuned on some surrogate loss, defeating theoretical advantages of Bayesian methods. The surrogate loss, defined to approximate the mixture, requires techniques as Monte Carlo sampling, increasing c…
Constrained tensor and matrix factorization models allow to extract interpretable patterns from multiway data. Therefore identifiability properties and efficient algorithms for constrained low-rank approximations are nowadays important research topics. This work deals with columns of factor matrices of a low-rank approximation being sparse in a known and possibly overcomplete basis, a model coined as Dictionary-based Low-Rank Approximation (DLRA). While earlier contributions focused on finding factor columns inside a dictionary of candidate columns, i.e. one-sparse approximations, this work is…
Massachusetts Institute of Technology（麻省理工学院）；London Business School（伦敦商学院）
We propose a unified framework to address a family of classical mixed-integer optimization problems with logically constrained decision variables, including network design, facility location, unit commitment, sparse portfolio selection, binary quadratic optimization, sparse principal analysis and sparse learning problems. These problems exhibit logical relationships between continuous and discrete variables, which are usually reformulated linearly using a big-M formulation. In this work, we challenge this longstanding modeling practice and express the logical constraints in a non-linear way. B…
Carnegie Mellon University（卡内基梅隆大学）；National University of Singapore（新加坡国立大学）
While linear mixed model (LMM) has shown a competitive performance in correcting spurious associations raised by population stratification, family structures, and cryptic relatedness, more challenges are still to be addressed regarding the complex structure of genotypic and phenotypic data. For example, geneticists have discovered that some clusters of phenotypes are more co-expressed than others. Hence, a joint analysis that can utilize such relatedness information in a heterogeneous data set is crucial for genetic modeling. We proposed the sparse graph-structured linear mixed model (sGLMM) t…
Fog manufacturing can greatly enhance traditional manufacturing systems through distributed Fog computation units, which are governed by predictive computational workload offloading methods under different Industrial Internet architectures. It is known that the predictive offloading methods highly depend on accurate prediction and uncertainty quantification of runtime performance metrics, containing multivariate mixed-type responses (i.e., continuous, counting, binary). In this work, we propose a Bayesian sparse regression for multivariate mixed responses to enhance the prediction of runtime p…
We consider a discrete optimization formulation for learning sparse classifiers, where the outcome depends upon a linear combination of a small subset of features. Recent work has shown that mixed integer programming (MIP) can be used to solve (to optimality) $\ell_0$-regularized regression problems at scales much larger than what was conventionally considered possible. Despite their usefulness, MIP-based global optimization approaches are significantly slower compared to the relatively mature algorithms for $\ell_1$-regularization and heuristics for nonconvex regularized problems. We aim to b…
We derive streamlined mean field variational Bayes algorithms for fitting linear mixed models with crossed random effects. In the most general situation, where the dimensions of the crossed groups are arbitrarily large, streamlining is hindered by lack of sparseness in the underlying least squares system. Because of this fact we also consider a hierarchy of relaxations of the mean field product restriction. The least stringent product restriction delivers a high degree of inferential accuracy. However, this accuracy must be mitigated against its higher storage and computing demands. Faster spa…
