噪声诱导早期生命自我复制子生物同手性的机制
A noise-induced mechanism for biological homochirality of early life self-replicators
摘要：
生物氨基酸和糖的单手性一直被认为是自催化作用的结果。然而，在确定性自催化系统中，同手性态的稳定性依赖于两种手性态的交叉抑制，这对于早期生命的自我复制者来说是不太可能的。在这里，我们提出了一个理论的随机个人水平的模型，由于早期生活的自我复制。在没有手性抑制的情况下，外消旋态是确定性动力学的全局吸引子，但在良好混合和空间扩展的系统中，固有的乘性噪声稳定了纯手性态。我们的结论是，自催化是一个可行的同手性机制，而不施加额外的非线性，如手性抑制。
英文摘要：
The observed single-handedness of biological amino acids and sugars has long been attributed to autocatalysis. However, the stability of homochiral states in deterministic autocatalytic systems relies on cross inhibition of the two chiral states, an unlikely scenario for early life self-replicators. Here, we present a theory for a stochastic individual-level model of autocatalysis due to early life self-replicators. Without chiral inhibition, the racemic state is the global attractor of the deterministic dynamics, but intrinsic multiplicative noise stabilizes the homochiral states, in both well-mixed and spatially-extended systems. We conclude that autocatalysis is a viable mechanism for homochirality, without imposing additional nonlinearities such as chiral inhibition.
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